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KMID : 0854720120320040268
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Korean Journal of Asthma, Allergy and Clinical Immunology
2012 Volume.32 No. 4 p.268 ~ p.271
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A Case of Vitamin K1 Induced Allergic Dermititis
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Sohn Kyung-Hee
Kim Ju-Young
Lee Suh-Young
Lee Seung-Eun
Kang Hye-Ryun
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Abstract
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Background: Vitamin K1 (phytonadione), a fat-soluble vitamin, has widely been used to correct bleeding tendency. Although delayed hypersensitivity to vitamin K in new borns is relatively well known, it has rarely been reported in adults.
Case History: A 39-year-old woman with thyroid cancer presented with eczematous erythema and severe itching
sense with local heat on her right buttock that occurred after intramuscular injection of vitamin K1 7 days ago. She had
received intramuscular injections of vitamin K1 to correct bleeding tendency before total thyroidectomy.
Results: The pathologic findings of a skin biopsy specimen revealed vacuolar dermatitis with perivascular inflammatory cell infiltration. The skin lesion rapidly improved after administration of oral prednisolone (30 mg/day), a topical steroid, and an oral antihistamine for 5 days. After resolution of the primary lesion, a patch test with vitamin K1 was
performed. The patient showed a positive reaction to vitamin K1 with an erythematous plaque with blistering at vitamin K1 injection site.
Conclusion: We report here in a case of vitamin K1-induced delayed hypersensitivity reaction confirmed by a patch test.
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KEYWORD
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Vitamin K1, Allergic contact dermititis, Delayed hypersensitivity
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